SAN DIEGO – Mark Loretta hit a bases-loaded sacrifice fly with one out in the 10th inning and the San Diego Padres beat San Francisco 4-3 Wednesday night to knock the Giants out of first place in the National League wild-card race.

The Padres didn’t have a hit in their winning rally, which was aided by two San Francisco errors. Right fielder Dustan Mohr tripped over the mound in the Giants’ bullpen down the right-field line as he caught Loretta’s flyball, and appeared to injure a knee. He remained on the ground for several minutes. Mohr had X-rays taken of his left knee, but results were not immediately known.

The Giants and Chicago Cubs had been tied for the wild-card lead going into Wednesday’s games but they both lost, allowing the Houston Astros to take the lead by a half game after beating St. Louis.

The Padres are 2> games back.

San Francisco remained three games behind Los Angeles in the NL West. After playing the Padres on Thursday night, the Giants head to Los Angeles for a season-ending, three-game series.

The Padres started the winning rally off Dustin Hermanson (6-8) when Ramon Hernandez reached on third baseman Edgardo Alfonzo’s throwing error. Freddy Guzman pinch-ran for Hernandez, and took third when catcher Yorvit Torrealba bounced a throw past first baseman Pedro Feliz for an error on Kerry Robinson’s sacrifice. Ramon Vazquez was intentionally walked to load the bases.

With the infield playing in, Guzman was forced at home on Jay Payton’s grounder to second. That brought up Loretta.

Trevor Hoffman (3-3) pitched two perfect innings for the win.

The Padres wasted two great scoring chances in the seventh and eighth innings. They stranded runners on first and second in the eighth, and left the bases loaded in the seventh.

Giants rookie left-hander Noah Lowry got a no-decision to remain undefeated in 14 big league starts. Lowry, trying to win his seventh straight decision, allowed Hernandez’s two-run homer to straightaway center field with one out in the sixth to tie the game at 3-3.

Rich Aurilia homered leading off the fourth. Aurilia singled ahead of Hernandez’s homer.

Lowry allowed three runs and six hits in six innings, struck out four and walked three.

David Wells pitched well in his final home start of the season for his hometown Padres. He went eight innings, allowing three runs on seven hits, striking out four and walking one.

The Giants took a 2-0 lead in the first on Feliz’s broken-bat, bloop double down the right-field line. Wells allowed Alfonzo’s single with two outs and walked Barry Bonds to bring up Feliz.

After Aurilia’s homer pulled the Padres to 2-1, the Giants scored again on Deivi Cruz’s RBI single in the fifth.