Randy Pausch, a Carnegie Mellon University computer scientist whose “last lecture” about facing terminal cancer became an international sensation and a best-selling book, died Friday.

Randy Pausch, a terminally ill professor whose earnest farewell lecture at Carnegie Mellon University became an Internet phenomenon and best-selling book that turned him into a symbol for living and dying well, died Friday. He was 47.

Pausch, who was a computer science professor and virtual-reality pioneer, died at his home in Chesapeake, Va., of complications from pancreatic cancer.

When Pausch agreed to give a theoretical “last lecture,” he was participating in a long-standing academic tradition. Except a month before giving the speech, the 46-year-old Pausch received the diagnosis that would heighten the poignancy of his address.

Originally delivered in September to about 400 students and colleagues, his message about how to make the most of life has been viewed by millions on the Internet. Pausch gave an abbreviated version of it on “Oprah” and expanded it into a best-selling book, “The Last Lecture,” released in April.

Yet Pausch insisted that both the spoken and written words were designed for an audience of three — his children, then 5, 2 and 1.

“I was trying to put myself in a bottle that would one day wash up on the beach for my children,” Pausch wrote in his book.

Unwilling to take time from his family to pen the book, Pausch hired a co-author, Jeffrey Zaslow, a Wall Street Journal writer who covered the lecture. During more than 50 bicycle rides crucial to his health, Pausch spoke to Zaslow via a cell phone headset.

“The speech made him famous all over the world,” Zaslow told the Los Angeles Times. “It was almost a shared secret, a peek into him telling his colleagues and students to go on and do great things. It touched so many people because it was authentic.”

If I don’t seem as depressed or morose as I should be, sorry to disappoint you.

He used that line after projecting CAT scans, complete with helpful arrows pointing to the tumors on his liver as he addressed “the elephant in the room” that made every word carry more weight.

As Pausch essentially said goodbye at Carnegie Mellon, he touched on just about everything but religion as he raucously relived how he achieved most of his childhood dreams. They included experiencing the weightlessness of zero gravity, writing an article in the World Book Encyclopedia (“You can tell the nerds early on,” he joked), becoming a Disney Imagineer, receiving a visit from Capt. Kirk from “Star Trek” and playing professional football.

Onstage, Pausch was a frenetic oral billboard, delivering as many one-liners as he did phrases to live by.

Experience is what you get when you didn’t get what you wanted.

When his virtual-reality students won a flight in a National Aeronautics and Space Administration training plane that briefly simulates weightlessness, Pausch was told faculty members were not allowed to fly. Finding a loophole, he applied to cover it as his team’s hometown Web journalist — and got his 25 seconds of floating.

Since 1997, Pausch had been a professor of computer science, human-computer interaction and design at Carnegie Mellon. With a drama professor, he founded the university’s Entertainment Technology Center, which teams students from the arts with those in technology to develop projects.

During the lecture, Pausch joked that he had become just enough of an expert to fulfill one childhood ambition. World Book sought him out to write its “virtual-reality” entry.

Actor William Shatner, who played Capt. Kirk, visited Pausch’s lab at Carnegie Mellon. Pausch believed that watching Kirk had taught him leadership skills. After the speech, Pausch was given a walk-on role in the “Star Trek” film due out in 2009.

Inside the auditorium, Pausch dared the crowd to overcome obstacles.

After his applications to become a Disney Imagineer repeatedly were rejected, Pausch said he talked his way into spending a sabbatical at the company’s virtual-reality studio. He helped design virtual-reality rides such as Aladdin’s Magic Carpet at Disney World.

Randolph Frederick Pausch was born Oct. 23, 1960, and raised in Columbia, Md. He liked to say he won the “parent lottery” with Fred and Virginia Pausch. His father sold insurance and his mother taught English.

As a teenager, he was allowed to paint whatever he wanted on his bedroom walls. His artistry included a quadratic equation, elevator doors and the rocket ship that adorns the cover of his book.

After graduating from Brown University with a bachelor’s degree in 1982, Pausch earned a doctorate in computer science from Carnegie Mellon in 1988. At the University of Virginia, he taught for nine years. When he got tenure, he thanked his research team by taking them to Disney World.

Although he didn’t make it to the National Football League, Pausch said playing high school football taught him to master fundamentals and accept criticism. A month after his speech, the Pittsburgh Steelers invited him to a practice. Pausch caught passes, grinning ear to ear.

Last autumn, he moved his family to southeastern Virginia so that Jai, his wife of eight years, could be near relatives. He tried to “build memories” with his children, taking his oldest, Dylan, to ride a dolphin and introducing his son Logan to Mickey Mouse at Disney World.

For his final Halloween, his family — including his youngest, daughter Chloe — went as the animated characters the Incredibles, personifying his end-of-life mantra:

We cannot change the cards we are dealt, just how we play the hand.

Weeks after his book was released, 2.3 million copies of it were in print. It is being published in 29 languages.

By the book’s end, Pausch sounds like a parent imparting advice as fast as he can. The chapters grow shorter as he tries to fit it all in: Don’t obsess over what people think. No job is beneath you. Tell the truth.

Ever the comedian, Pausch delighted in his mother’s use of humor to keep him humble.

After I got my Ph.D., my mother took great relish in introducing me as, “This is my son. He’s a doctor, but not the kind that helps people.”

His mother couldn’t have been more wrong.

In addition to his wife Jai and three children, Pausch is survived by his mother and a sister.