HOUSTON — Peyton Manning turned a colossal collapse by the Houston Texans into a stunning victory for the Indianapolis Colts.

The Colts scored 21 points in a late span of 2:10 — two touchdowns thanks to fumbles by Sage Rosenfels — then intercepted Rosenfels’ last-ditch comeback attempt for a 31-27 win Sunday.

Manning threw two touchdown passes, connecting with Reggie Wayne on a 5-yarder with 1:54 remaining for the decisive points. Linebacker Gary Brackett returned a fumble by quarterback Rosenfels 68 yards for a score in between Manning’s TD throws.

Rookie Tom Santi caught the other late score, a 7-yarder to bring the Colts (2-2) within 27-17 with 4:04 to go. It was his first NFL touchdown.

Backup Rosenfels, playing for the ill Matt Schaub, had the winless Texans (0-4) ahead by 17 points before losing two fumbles and throwing an interception. Texans fans had wanted to see Schaub replaced all season, and Rosenfels was nearly flawless for three quarters. Then came one of the worst collapses in the history of the young franchise.

After Manning found Santi for his touchdown, Indianapolis attempted an onside kick, but Houston recovered. On the next drive, Rosenfels ran right at defensive back Marlin Jackson, who upended him and knocked the ball loose. Brackett ran it in to make it 27-24.

On the ensuing drive, Robert Mathis sacked Rosenfels and stripped the ball at the Houston 19. Manning hit a leaping Wayne in the corner of the end zone, the play was reviewed, and the call was upheld.

The Texans played the 100th game in franchise history in their hurricane-damaged stadium with the retractable roof open; the roof couldn’t be repaired in time for Sunday’s game. Houston was supposed to host Baltimore in Week 2 when Hurricane Ike hit, but that game was postponed until Nov. 9.

In other games on Sunday:

Cardinals 41

Bills 17

GLENDALE, Ariz. — The Bills lost their quarterback and, emphatically, their first game of the season. Second-year quarterback Trent Edwards went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game. It was the Bills’ defense that collapsed after that. Rookie Tim Hightower had a pair of touchdown runs for Arizona and Kurt Warner threw to Larry Fitzgerald twice for scores.

Broncos 16

Buccaneers 13

DENVER — The high-flying Broncos finally discovered a defense, generating a pass rush that sent Brian Griese to the sideline with an injured throwing shoulder. Jay Cutler guided a patient Denver offense over the Buccaneers (3-2). Brandon Stokley hauled in Cutler’s pass in the right flat and followed Brandon Marshall’s big block for a 10-yard touchdown and Matt Prater kicked three field goals for Denver.

Cowboys 31

Bengals 22

IRVING, Texas — After letting a 17-point lead shrivel to one, then breaking up a two-point conversion that could have tied it, the Cowboys had plenty of reasons to celebrate. Dallas (4-1) led 17-0 after only three drives, but ended up needing big plays from Terrell Owens, Tank Johnson and Keith Davis to stave off the bumbling Bengals (0-5).

Patriots 30

49ers 21

SAN FRANCISCO — From Randy Moss’ dynamic 66-yard touchdown catch to Kevin Faulk’s score on a direct snap, the Patriots returned to their usual regular-season form in an unusual place. Faulk rushed for two scores, Matt Cassel had 259 yards passing and the Patriots won in San Francisco for the first time in franchise history.

Dolphins 17

Chargers 10

MIAMI — The Dolphins are winning the old-fashioned way. The single wing helped build a lead, and a goal-line stand preserved it. Ronnie Brown scored the decisive touchdown from the formation the Dolphins revived two weeks ago, their smothering defense rose to the occasion at the 1-yard line in the fourth quarter, and Miami pulled off its second successive upset.

Titans 13

Ravens 10

BALTIMORE — The Titans are still unbeaten thanks to a late touchdown drive and a defense that outperformed the top-ranked unit in the league. Kerry Collins threw an 11-yard touchdown pass to Alge Crumpler with 1:56 left. The Titans (5-0) trailed 10-6 before Collins directed an 11-play, 80-yard scoring drive. The march was aided by a penalty against Baltimore’s Terrell Suggs, who was flagged for a blow to Collins’ helmet — although the hit appeared to be little more than incidental contact.

Giants 44

Seahawks 6

EAST RUTHERFORD, N.J. — The Giants are this year’s New England Patriots — so far. In a nearly flawless performance, Eli Manning threw two touchdowns, Brandon Jacobs ran for two more and the unbeaten Giants scored on their first five possessions.

Falcons 27

Packers 24

GREEN BAY, Wis. — Aaron Rodgers played hurt and played hard. But he was upstaged by Matt Ryan and the Falcons. Atlanta’s rookie quarterback turned in another sharp performance, completing 16 of 26 passes for 194 yards, two touchdowns and an interception against the banged-up Packers.

Redskins 23

Eagles 17

PHILADELPHIA — Another road win against a division opponent has the Redskins in perfect position to make a run at the NFC East. Clinton Portis ran for 145 yards and one touchdown and wide receiver Antwaan Randle El threw a TD pass.

Panthers 34

Chiefs 0

CHARLOTTE, N.C. — DeAngelo Williams had 123 yards rushing and scored three touchdowns and the Panthers handed the Chiefs their first shutout in nearly six years. Williams and Jonathan Stewart ran through a woeful defense that also couldn’t stop the pass. Steve Smith caught six passes for 96 yards, Muhsin Muhammad had a 47-yard touchdown catch and the Panthers moved to 3-0 at Bank of America Stadium after going 2-6 at home last season.

Bears 34

Lions 7

DETROIT — Kyle Orton set career highs in yards passing, completions and quarterback rating while throwing two touchdowns. He was 24-of-34 for 334 yards and had a 121.4 rating, improving to 3-0 against the Lions. Orton connected with Devin Hester for a touchdown and Charles Tillman intercepted a pass that went off Roy Williams’ hands and returned it for a score. Chicago (3-2) broke a first-place tie with the Packers to lead the lackluster NFC North.

Steelers 26

Jaguars 21

JACKSONVILLE, Fla. — Big Ben’s big night gave Pittsburgh a big boost in the AFC North. Ben Roethlisberger threw for 309 yards and three touchdowns, helping the Steelers overcome their offensive woes and leading them to a victory over Jacksonville. Pittsburgh (4-1) snapped a four-game losing streak against Jacksonville and stretched its division lead over Baltimore (2-2), which lost to Tennessee earlier in the day.