William Safire, a speechwriter for President Richard M. Nixon and a Pulitzer Prize-winning political columnist for The New York Times who also wrote novels, books on politics and a Malaprop’s treasury of articles on language, died at a hospice in Rockville, Md., on Sunday. He was 79.

The cause was pancreatic cancer, said Martin Tolchin, a friend of the family.

There may be many sides in a genteel debate, but in the Safire world of politics and journalism it was simpler: There was his own unambiguous wit and wisdom on one hand and, on the other, the blubber of fools he called “nattering nabobs of negativism” and “hopeless, hysterical hypochondriacs of history.”

He was a college dropout and proud of it, a public relations go-getter who set up the famous Nixon-Khrushchev “kitchen debate” in Moscow, and a White House wordsmith in the tumultuous era of war in Vietnam, Nixon’s visit to China and the gathering storm of the Watergate scandal, which drove the president from office.

From 1973 to 2005, Safire wrote his “Essay” for the Op-Ed Page of The Times in a forceful conservative voice. He won the 1978 Pulitzer Prize for commentary, and for 32 years tenaciously attacked and defended foreign and domestic policies, and the foibles, of seven administrations.

Safire also wrote four novels, including “Full Disclosure” (Doubleday, 1977), a best-seller about succession issues after a president is blinded in an assassination attempt, and nonfiction that included “The New Language of Politics” (Random House, 1968), and “Before the Fall” (Doubleday, 1975), a memoir of his White House years.

And he wrote “On Language,” a syndicated column published in The Bulletin, that explored written and oral trends, plumbed the origins and meanings of words and phrases, and drew a devoted following.