Indianapolis Colts quarterback Peyton Manning, middle, reacts with teammates after throwing a touchdown during the fourth quarter against the New England Patriots in Indianapolis on Sunday.

INDIANAPOLIS — Bill Belichick risked everything on one play Sunday night.

It cost him a victory, and it may wind up costing him a trip back to Indianapolis for a rematch with Peyton Manning later this season.

After the New England coach failed on a stunning gamble deep in his own territory, Manning threw a 1-yard touchdown pass to Reggie Wayne with 13 seconds left that rallied the unbeaten Colts to a 35-34 win over the Patriots.

“It’s a bummer,” Patriots quarterback Tom Brady said.

Needing a first down to seal the game, Belichick decided to go for it on fourth-and-2 from his own 28 with 2:08 to go. The Patriots called their second timeout of the drive, leaving them with none, to set up the play: A short pass from Brady to Kevin Faulk, something the 2007 NFL MVP had repeatedly used to burn Indy’s young, depleted pass defense all night.

Not this time.

Faulk made a juggling catch but safety Melvin Bullitt, who replaced Bob Sanders in the lineup, came straight up the field and drove the Patriots running back into the ground a half-yard short of the marker.

“We tried to win the game on that play,” Belichick explained. “I thought we could make the yard. We had a good play, we completed it. I don’t know how we couldn’t get a yard.”

It was the most improbable victory for the Colts (9-0) in their 18-game regular-season winning streak, which is now tied for the second-longest in league history with, of all teams, New England.

The Colts trailed by 17 points early in the fourth quarter. This marked the first time Belichick’s Patriots had lost when leading by at least 13 in the final period.

“When you see them going for it on fourth down, you get a little nervous, but our defense blitzed them, pressured them and got the stop,” Manning said. “It certainly changed our philosophy. In practice, we’re going 60 or 70 yards. So we figure we’re going to have to go five, six, seven plays. In the huddle, I said, ‘Obviously, we need a touchdown, but let’s not be in a hurry.”

Also on Sunday:

Cardinals 31

Seahawks 20

GLENDALE, Ariz. — Rookie Beanie Wells had second-half touchdown runs of 10 and 13 yards and Arizona rallied from an early two-touchdown deficit for its second home win in five tries. Kurt Warner completed 29 of 38 for 340 yards and two touchdown passes as the Cardinals (6-3) stayed two games up on San Francisco in the NFC West. Warner also became the 29th player in NFL history to throw 200 touchdown passes, and had his 51st 300-yard passing game, tying Dan Fouts for fourth on the NFL career list. With Julius Jones out early with a chest injury, second-year back Justin Forsett rushed for a career-high 123 yards, including an 11-yard touchdown run, for the Seahawks (3-6). Matt Hasselbeck, who had been bothered by a sore shoulder, was 26 of 52 for 315 yards and a touchdown. He was picked off twice late in the game.

Bengals 18

Steelers 12

PITTSBURGH — Cincinnati beat the Steelers at their own game in their own stadium, relying on a defense that smothered Ben Roethlisberger and the Super Bowl champions by holding them to four field goals, and using one big special teams play for a win that put them in control of the AFC North. Shayne Graham kicked four field goals in the second half even as the Bengals (7-2) failed to convert opportunity after opportunity to take control. Bernard Scott’s 96-yard kickoff return in the first quarter proved pivotal for Cincinnati.

Dolphins 25

Bucs 23

MIAMI — Chad Henne directed a 77-yard scoring drive in the final 1:10, and Dan Carpenter kicked a 25-yard field goal with 10 seconds left. Henne spoiled the Bucs’ comeback led by Josh Freeman, who rallied his team in the fourth quarter for the second time in two NFL starts. The rookie shook off an awful first half and led his team to a pair of late touchdowns. The Dolphins (4-5) won despite losing running back Ronnie Brown to a right ankle injury in the third quarter.

Saints 28

Rams 23

ST. LOUIS — Reggie Bush helped the unbeaten New Orleans Saints overcome another bundle of mistakes and get off to the best start in team history. Bush scored twice for the first time in more than a year and Drew Brees compensated for two interceptions with two touchdown passes in the win. Courtney Roby opened the second half with a 97-yard kickoff return and Robert Meachem’s 27-yard grab early in the fourth quarter gave New Orleans (9-0) just enough breathing room to tie the franchise record with nine straight wins.

Panthers 28

Falcons 19

CHARLOTTE, N.C. — Jake Delhomme went turnover-free for the third straight game, finding Steve Smith for two touchdowns. The Panthers (4-5) built a 21-10 halftime lead, but the win wasn’t sealed until Richard Marshall picked off Atlanta quarterback Matt Ryan, setting up Jonathan Stewart’s 45-yard touchdown run with 2:07 left. Earlier, Jason Elam missed a 34-yard field goal that would have given Atlanta (5-4) the lead.

Vikings 27

Lions 10

MINNEAPOLIS — Brett Favre passed for a season-high 344 yards, 201 to Sidney Rice, and Detroit lost for the 31st time in 33 games. The Lions (1-8) joined the Houston Oilers, from Nov. 21, 1982 through Nov. 4, 1984, as the only NFL teams to lose 31 games in a 33-game stretch, according to STATS. Adrian Peterson lost a fumble but turned 18 carries into 133 yards and two touchdowns for Minnesota (8-1).

Redskins 27

Broncos 17

LANDOVER, Md. — Washington broke the 17-point barrier for the first time this season and ended a four-game losing streak. The Broncos lost their third straight and had to play the second half with Chris Simms at quarterback after Kyle Orton left with an ankle injury. Denver (6-3) has struggled since opening the season with six wins. Ladell Betts scored on a 1-yard run with 2:44 to play for the Redskins.

Titans 41

Bills 17

NASHVILLE, Tenn. — Chris Johnson ran for 132 yards and two touchdowns, and he caught nine passes for 100 more. The Titans (3-6) are on a roll since opening the season 0-6, and they can thank Johnson, the NFL’s leading rusher and the league’s first back to top 1,000 yards this season.

Jaguars 24

Jets 22

EAST RUTHERFORD, N.J. — Josh Scobee kicked a 21-yard field goal as time expired after the Jaguars passed up a touchdown in order to drain the clock. With the Jaguars facing second-and-6 from the 10, Maurice Jones-Drew took a handoff up the middle and went to a knee at the 1 to give Jacksonville first and goal with just over a minute left. New York had no timeouts left. David Garrard knelt the ball twice, giving Scobee the opportunity to kick the game winner for the Jaguars (5-4).

Chargers 31

Eagles 23

SAN DIEGO — LaDainian Tomlinson scored twice to continue his climb up the career rushing and scoring lists, and San Diego pulled into a tie atop the AFC West. Tomlinson gained a season-high 96 yards on 24 carries to pass Thurman Thomas and Franco Harris and move into 12th place all-time with 12,145 yards. His two touchdowns gave him 146 and moved him past Marcus Allen and into third place on the all-time list. Donovan McNabb threw for a season-high 450 yards, completing 35 of 55, and two late touchdowns for Philadelphia (4-5).

Chiefs 16

Raiders 10

OAKLAND, Calif. — Jamaal Charles scored on a 44-yard run for Kansas City’s first rushing touchdown of the season and the Chiefs used a late interception to win their seventh straight game in Oakland. The Chiefs (2-7) have managed to win just five of their past 35 games. But three of those wins have come at the Oakland Coliseum, where Kansas City has the longest winning streak ever by a visiting team.

Packers 17

Cowboys 7

GREEN BAY, Wis. — Charles Woodson helped Green Bay’s defense finally play up to its potential against a big-time opponent, forcing two fumbles and picking off a pass by Tony Romo on the goal line. It wasn’t a pretty win for the Packers (5-4), but it might have saved their season after back-to-back demoralizing losses. The Packers sacked Romo five times and held him to 251 yards passing in a momentum- killer for the Cowboys (6-3), who had won four straight.