LOS ANGELES — Gary Winick, a pioneering producer and director of independent digital films who found mainstream success with such movies as “13 Going on 30” and “Letters to Juliet,” has died. He was 49.

Winick, who was diagnosed with brain cancer about two years ago, died Sunday at Beth Israel Medical Center in New York City, said Niels Mueller, a longtime collaborator.

When Winick went to the Sundance Film Festival in 2002, he didn’t even have an agent. He screened the sixth film he made as a director, “Tadpole,” a coming-of-age comedy made in two weeks with digital cameras for a reported $150,000.

After he earned the festival’s directing award, and Miramax paid $5 million for distribution rights to “Tadpole,” Hollywood came calling.

His first big-budget directing project was the 2004 fantasy-romantic comedy “13 Going on 30.”

He followed that with “Charlotte’s Web,” a 2006 live-action remake.

The two-plus years that Winick spent making “Charlotte’s Web” pulled his attention away from InDigEnt — for Independent Digital Entertainment — the all-digital production company he co-founded in 1999 that became the industry’s digital filmmaking leader.

With InDigEnt, Winick “saw an opportunity to attract young talent by marrying the rock-bottom economics of digital video with the creative intimacy of the medium,” Patrick Goldstein wrote in the Times in 2002.

InDigEnt gained notice for such Winick-produced films as Richard Linklater’s “Tape” (2001); “Personal Velocity: Three Portraits” (2002); and the comedy-drama “Pieces of April” (2003), which earned actress Patricia Clarkson an Oscar nomination.