LONDON — Ford pressed ahead Thursday with its plan to slash production in Europe, announcing another plant closure and 1,500 more job cuts, as it warned that annual losses in the region will exceed $1.5 billion this year and next.

Ford Motor Co. is struggling in Europe, like many major carmakers, because labor costs are relatively high and there are too many plants given that demand for cars is sliding due to the economic crisis. Worries about its European business have dragged down Ford’s stock price this year.

A day after announcing the closure of a major plant in Belgium, Ford said it also will close its Transit van plant in Southampton, Britain, and the stamping and tooling facility at its plant in Dagenham, east London.

The actions announced this week — along with a previously announced initiative to cut about 500 salaried and agency positions across Europe — affect a total of 6,200 Ford jobs, or about 13 percent of the company’s European workforce.

Counting the indirect impact on suppliers that depend on doing business with Ford’s factories, the plant closures will cause about 11,000 job losses.

“We recognize the impact our actions will have on many employees and their families in Europe, and we will work together with all stakeholders during this necessary transformation of our business,” said Ford’s president and CEO, Alan Mulally.

Len McCluskey, general secretary of Britain’s Unite union, said workers would fight against the closures.

“This announcement has been handled disgracefully,” McCluskey said “Only a few months ago Ford was promising staff a new Transit model for Southampton in 2014.”

The company said it needs to cut costs in Europe, where it will try to refocus its operations on fuel-efficient motors and safety technologies. It expects the European business to return to profitability by mid-decade, thanks to the plant closures and the introduction of new models.

Despite the losses in Europe, Ford still expects a strong pretax profit this year for the company overall. Earnings will be better in the third quarter than in the second, excluding one-time costs and gains.

The Southampton plant, which employs 500 workers and will be shut in July, is Ford’s last vehicle assembly plant in Britain. Production there has fallen from 66,000 vehicles in 2008 to 28,000 last year. Transit van production will be consolidated at the plant in Kocaeli, Turkey.

At the Dagenham plant, where it will close a stamping facility in 2013, Ford promised to invest in the production of a new series of 20-liter, four-cylinder, low-CO2 diesel engines. It will also invest at the Bridgend plant in Wales to support gasoline engine manufacturing.

Closing the Belgian and British plants reduces vehicle assembly capacity, excluding Russia, by 18 percent, or 355,000 units, yielding annual savings of at least $450 million, Ford said.