PARIS — Novak Djokovic was laying on his back on a French Open sideline early in the second set Monday, wincing while his bothersome right knee was manipulated by a trainer. A couple of hours of stumbling and limping later, Djokovic found himself down by a set and a break against a younger, eager opponent.

Ah, but this is Novak Djokovic, who never met an obstacle too daunting or a deficit he couldn’t overcome.

Doing what he does so well, and coming back to win in five sets across about 4 1/2 hours for the second consecutive time, Djokovic surged past No. 23 Francisco Cerundolo 6-1, 5-7, 3-6, 7-5, 6-3 in the fourth round at Roland Garros for his record 370th win in a Grand Slam match.

Djokovic, ranked No. 1 and the defending champion in Paris, broke a tie with Roger Federer for the most match wins at major tournaments — and also for the most Slam quarterfinals for a man by reaching the 59th of his career.