Dikembe Mutombo, a Basketball Hall of Famer who was one of the best defensive players in NBA history and a longtime global ambassador for the game, died Monday from brain cancer, the league announced. He was 58.

His family revealed two years ago that he was undergoing treatment in Atlanta for a brain tumor. The NBA said he died surrounded by his family.

“Dikembe Mutombo was simply larger than life,” NBA Commissioner Adam Silver said. “On the court, he was one of the greatest shot blockers and defensive players in the history of the NBA. Off the floor, he poured his heart and soul into helping others.”

Mutombo was distinctive in so many ways — the playful finger wag at opponents after blocking their shots, his height, his deep and gravelly voice, his massive smile. Players of this generation were always drawn to him and Philadelphia 76ers star Joel Embiid, who was born in Cameroon, looked to Mutombo as an inspiration.

“It’s a sad day, especially for us Africans, and really the whole world,” Embiid said Monday.

Mutombo spent 18 seasons in the NBA, playing for Denver, Atlanta, Houston, Philadelphia, New York and the then-New Jersey Nets. The 7-foot-2 center out of Georgetown was an eight-time All-Star, three-time All-NBA selection and went into the Hall of Fame in 2015 after averaging 9.8 points and 10.3 rebounds per game for his career.

Mutombo last played during the 2008-09 season, devoting his time after retirement to charitable and humanitarian causes. He spoke nine languages and founded the Dikembe Mutombo Foundation in 1997, concentrating on improving health, education and quality of life for the people in the Congo.

Ryan Mutombo, the Hall of Famer’s son, said in a tribute posted on social media that his father “loved others with every ounce of his being.”

“My dad is my hero because he simply cared,” Ryan Mutombo wrote. “He remains the purest heart I have ever known.”

Mutombo served on the boards of many organizations, including Special Olympics International, the CDC Foundation and the National Board for the U.S. Fund for UNICEF.

Mutombo is one of three players to win the NBA’s Defensive Player of the Year four times. The others: reigning DPOY winner Rudy Gobert of the Minnesota Timberwolves, and Hall of Famer Ben Wallace.