More than two decades on the road gave Martin Sexton plenty to write about.

The Syracuse, New York, singer-songwriter’s latest album, 2015’s “Mixtape of the Open Road,” features 12 songs that take listeners from New England to northern California and just about everywhere else in between. Along the way, Sexton touches on just about every style in his musical playbook — including blue-eyed soul, breezy pop, rock, folk and more.

One place Sexton’s never been in his years of touring: Central Oregon. He’ll rectify that Wednesday when he plays Sisters High School as part of Sisters Folk Festival’s winter concert series.

In an email interview, Sexton talked about the album, getting his songs placed on TV show “Scrubs” and his early days busking in Boston.

Q: First of all, where are you right now?

A: I’m at my favorite deli in the U.S. — Canter’s in Hollywood.

Q: How is the tour going? Who’s on the road with you right now, and who will be here for the show with the Sisters Folk Festival?

A: Right now I have The Accidentals as support — a great young band from Michigan — and Toca Rivera sitting in with me on percussion in Southern California. Lots of fun.

Q: You posted a video on your Facebook page of your “mashup tribute” to David Bowie, Sharon Jones, Prince, Leonard Cohen, Glenn Fry, George Michael, Merle Haggard and Leon Russell. Given all these artists’ unique styles and voices, was it a challenge putting their songs together in this way?

A: It was a challenge putting together all these songs and styles, so I just took a tip from side B of Abbey Road and figured out what part of what song would meet the next in some cohesive fashion.

Q: What has audience reaction been to “Mixtape of the Open Road”?

A: It’s been great. I’m getting requests for songs on that record every night.

Q: You’ve talked in past interviews about road-testing these songs before you recorded them. Have they continued to evolve in the live setting since the recording, and how so?

A: Pretty much every one of my songs departs from the album version as I tour behind them. It’s just an artistic flow that seems to happen each night.

Q: And with that said, can audiences expect any new songs on this tour?

A: I’ve been throwing in some stuff on this tour.

Q: Explain the title “Mixtape of the Open Road”?

A: It’s like that mixtape you made for a friend after graduation or a breakup or a road trip. It’s a collection of songs from many different schools of music that I wrote all over North America over the years.

Q: What was the writing and recording process like this time around?

A: I recorded it live on the floor like most of my records — and I played bass on all the tracks, which was fun for me — as well as all the guitars, vocals and various percussive things like buckets and water jugs.

Q: How do you approach writing a song? Has that approach changed at all over the years from your first song to now? Has it gotten easier or harder as you’ve written more?

A: Songwriting has not gotten easier for me over the years. Several of the songs (on “Mixtape of the Open Road”) were co-written. I find songwriting to be like chiseling a statue out of a hunk of granite.

Q: What were some of the most important things you learned about performing when you were busking in Boston? How did that experience affect your live performances in more traditional concert settings? Is it still something you draw from onstage?

A: Busking was like my performance school. I learned not only how to attract a crowd but how to keep a crowd and some of those skills I still use in every show.

Q: You’ve had songs placed in a number of TV shows and films. Any of these particularly stand out in your mind as a favorite? How important are these placements, especially given where the music industry is at today?

A: My song “Diner” on “Scrubs” is the one that stands out as the most impactful, as it was not only on two episodes and their soundtrack but the YouTube views of the clips were in the millions.

Q: Finally, is there anything else you would like to add?

A: Looking forward to playing central Oregon for the first time!